Home Print this page Email this page Small font size Default font size Increase font size   Users Online: 523
Home About us Editorial board Search Browse articles Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 1  |  Page : 13

Evaluation of enzyme activity and rate of tooth movement in corticotomy-accelerated tooth movement – A randomized clinical trial


1 Department of Orthodontics and Dentofacial Orthopedics, Uttaranchal Dental and Medical Research Institute, Majri Grant, Doiwala, Dehradun, Uttarakhand, India
2 Department of Endodontics and Conservative Dentistry, Uttaranchal Dental and Medical Research Institute, Majri Grant, Doiwala, Dehradun, Uttarakhand, India
3 Department of Periodontology, Uttaranchal Dental and Medical Research Institute, Majri Grant, Doiwala, Dehradun, Uttarakhand, India
4 Department of Periodontology, Hazaribag College of Dental Sciences and Hospital, Demotand, Hazaribag, Jharkhand, India
5 Department of Periodontology, Universal College of Medical Sciences, Bhairahwa, Nepal

Correspondence Address:
Dr. Vivek Kumar
House No. 308/A, Prasad Flour Mill Road, Doranda, Ranchi, Jharkhand
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jos.JOS_76_18

Rights and Permissions

BACKGROUND: This study was undertaken to evaluate the enzyme activity profiles in human saliva and gingival crevicular fluid (GCF) in accelerated tooth movement when compared with normal orthodontic tooth movement (OTM) in extraction cases. MATERIALS AND METHODS: Twenty patients who required premolar extractions were treated with MBT mechanotherapy. They were divided into two equal groups: conventional (Group I) and corticotomy (Group II) which was performed on both the jaw sides before initiating retraction. GCF was collected from mesial and distal aspects of canine before initiation of retraction and at 7th, 14th, 21st, and 28th days, and then at fifth and sixth weeks and third and sixth months after retraction. A total of 5 mL of unstimulated saliva was collected from the subjects after 90 min of nonoral activity (subjects were refrained from eating and drinking). RESULTS: The results showed that in Group I, the peak of aspartate aminotransferase (AST) and alkaline phosphatase (ALP) enzyme activity occurred on the 14th day of force application. In Group II, the enzyme activity progressively increased from day 0 to 6 weeks, peaking at the sixth week, and then a decline in enzyme activity was observed on third and sixth months. When ALP and AST activities in GCF and saliva were compared between Groups I and II, no statistically significant difference was observed on days 0, 7, and 14. CONCLUSION: Corticotomy-accelerated tooth movement is a promising technique that has many applications in orthodontic treatment of adults as it helps overcome many of the current limitations of this treatment. The enzymatic activity signifies osteoclastic and osteoblastic activities, so ALP and AST from the saliva and GCF may potentially be used as biomarkers for monitoring corticotomy-assisted OTM.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed191    
    Printed16    
    Emailed0    
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal